diff --git a/hw/virtio/vhost-user-i2c.c b/hw/virtio/vhost-user-i2c.c
index 60eaf0d95b..4eef3f0633 100644
--- a/hw/virtio/vhost-user-i2c.c
+++ b/hw/virtio/vhost-user-i2c.c
@@ -128,6 +128,14 @@ static void vu_i2c_guest_notifier_mask(VirtIODevice *vdev, int idx, bool mask)
 {
     VHostUserI2C *i2c = VHOST_USER_I2C(vdev);
 
+    /*
+     * We don't support interrupts, return early if index is set to
+     * VIRTIO_CONFIG_IRQ_IDX.
+     */
+    if (idx == VIRTIO_CONFIG_IRQ_IDX) {
+        return;
+    }
+
     vhost_virtqueue_mask(&i2c->vhost_dev, vdev, idx, mask);
 }
 
@@ -135,6 +143,14 @@ static bool vu_i2c_guest_notifier_pending(VirtIODevice *vdev, int idx)
 {
     VHostUserI2C *i2c = VHOST_USER_I2C(vdev);
 
+    /*
+     * We don't support interrupts, return early if index is set to
+     * VIRTIO_CONFIG_IRQ_IDX.
+     */
+    if (idx == VIRTIO_CONFIG_IRQ_IDX) {
+        return false;
+    }
+
     return vhost_virtqueue_pending(&i2c->vhost_dev, idx);
 }